import time
header = {
"partnerId": "4480006",
"poiId": "571396397",
"startTime": 1669824000000,
"endTime": 1686931199999,
"filter": "ALL",
"invoiceMark": 0,
"offset":  +10,
"limit": 10,
"zlPois":"",
"_mtsi_eb_u":108844675,
"_mtsi_eb_p":4480006,
"optimus_uuid":4480006,
"optimus_risk_level":71,
"optimus_code":10,
"login_type":"unknown",
}

str1 = '2022-03-02'
time_stamp = int(time.mktime(time.strptime(str1, '%Y-%m-%d')))
print(time_stamp)  # 输出 1646257800