diff --git a/src/debug/debug-interface.cc b/src/debug/debug-interface.cc
index 684347b0f09a05143c8d71b67fde6340d0c8322f..97ea9a822cfc1a646342c17cc2736194a4d6ee36 100644
--- a/src/debug/debug-interface.cc
+++ b/src/debug/debug-interface.cc
@@ -475,8 +475,8 @@ int Script::GetSourceOffset(const Location& location) const {
   i::Handle<i::Script> script = Utils::OpenHandle(this);
 #if V8_ENABLE_WEBASSEMBLY
   if (script->type() == i::Script::TYPE_WASM) {
-    DCHECK_EQ(0, location.GetLineNumber());
-    return location.GetColumnNumber();
+   return location.GetLineNumber() == 0 ? Just(location.GetColumnNumber())
+                                        : Nothing<int>();
   }
 #endif  // V8_ENABLE_WEBASSEMBLY
 
diff --git a/test/inspector/inspector.status b/test/inspector/inspector.status
index c74a09a3dee42f2716eff4840e6e421e75981804..54e9e5823c785bd060e4b125cf788ae5981446fc 100644
--- a/test/inspector/inspector.status
+++ b/test/inspector/inspector.status
@@ -58,6 +58,7 @@
   'debugger/wasm-*': [SKIP],
   'cpu-profiler/console-profile-wasm': [SKIP],
   'runtime/get-properties': [SKIP],
+  'regress/regress-crbug-349248170': [SKIP],
 }],  # not has_webassembly or variant == jitless
 
 ##############################################################################
diff --git a/test/inspector/regress/regress-crbug-349248170-expected.txt b/test/inspector/regress/regress-crbug-349248170-expected.txt
new file mode 100644
index 0000000000000000000000000000000000000000..72122506f5118d44ec0c27707cb55dc6666b6593
--- /dev/null
+++ b/test/inspector/regress/regress-crbug-349248170-expected.txt
@@ -0,0 +1,10 @@
+Don't crash when using non-zero line number to set WASM breakpoint
+Waiting for wasm script to be parsed.
+Setting breakpoint in wasm.
+{
+    error : {
+        code : -32000
+        message : Could not resolve breakpoint
+    }
+    id : <messageId>
+}
\ No newline at end of file
diff --git a/test/inspector/regress/regress-crbug-349248170.js b/test/inspector/regress/regress-crbug-349248170.js
new file mode 100644
index 0000000000000000000000000000000000000000..a043452e07b22a22228d5cd5dbfc2de7bf539996
--- /dev/null
+++ b/test/inspector/regress/regress-crbug-349248170.js
@@ -0,0 +1,52 @@
+// Copyright 2024 the V8 project authors. All rights reserved.
+// Use of this source code is governed by a BSD-style license that can be
+// found in the LICENSE file.
+
+// Adapted test from 'inspector/debugger/wasm-externref-global.js'
+
+utils.load('test/inspector/wasm-inspector-test.js');
+
+const {session, contextGroup, Protocol} =
+  InspectorTest.start('Don\'t crash when using non-zero line number to set WASM breakpoint');
+
+(async () => {
+  let builder = new WasmModuleBuilder();
+  builder.addImportedGlobal('m', 'global', kWasmExternRef, false);
+  let func = builder.addFunction('func', kSig_v_v)
+    .addBody([
+      kExprGlobalGet, 0,  //
+      kExprDrop,          //
+    ])
+    .exportAs('main');
+  let moduleBytes = JSON.stringify(builder.toArray());
+
+  function test(moduleBytes) {
+    let module = new WebAssembly.Module((new Uint8Array(moduleBytes)).buffer);
+    let global = 'hello, world';
+    instance = new WebAssembly.Instance(module, { m: { global } });
+  }
+
+  Protocol.Debugger.enable();
+  Protocol.Runtime.evaluate({
+    expression: `
+      let instance;
+      ${test.toString()}
+      test(${moduleBytes});`
+  });
+
+  InspectorTest.log('Waiting for wasm script to be parsed.');
+  let scriptId;
+  while (true) {
+    let msg = await Protocol.Debugger.onceScriptParsed();
+    if (msg.params.url.startsWith('wasm://')) {
+      scriptId = msg.params.scriptId;
+      break;
+    }
+  }
+
+  InspectorTest.log('Setting breakpoint in wasm.');
+  InspectorTest.logMessage(await Protocol.Debugger.setBreakpoint(
+    { location: { scriptId, lineNumber: 42, columnNumber: func.body_offset } }));
+
+  InspectorTest.completeTest();
+})();
\ No newline at end of file